Beilstein J. Org. Chem.2015,11, 2689–2695, doi:10.3762/bjoc.11.289
Pietro Castellino 111, 80131 Napoli, Italy 10.3762/bjoc.11.289 Abstract Cyclic N1-pentylinosine monophosphate (cpIMP), a novel simplified inosine derivative of cyclicADP-ribose (cADPR) in which the N1-pentyl chain and the monophosphate group replace the northern ribose and the pyrophosphate moieties
neuronal cells.
Keywords: calcium mobilization; cIDPR analogues; cyclicADP-ribose (cADPR); cyclization; Introduction
Nucleosides and nucleotides (NNs) are widely used as key intermediates and important core structures in the field of synthetic medicinal chemistry [1][2]. They represent versatile
]. Among these NNs there is the cyclicADP-ribose (cADPR 1, Figure 1), a metabolite strictly involved in the homeostasis of cellular calcium ions. cADPR is a second messenger that activates the ryanodine receptors of the sarcoplasmic reticulum and mobilizes Ca2+ ions in many cell types of protozoa, plants
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Graphical Abstract
Figure 1:
Structures of cADPR (1), cIDPR (2), cpIDP (3) and cpIMP (4).